The developing mammalian brain is one of the most dynamic of biological
systems involving numerous cell types each with its own repertoire of
gene expression and behavior. This application is designed to use two
special mouse-based resources, recombinant inbred lines and single
gene mutants, to produce a large set of molecular and cellular data
which will be submitted to informatic tools developed within this project
to allow the research community to interactively query the databases to
provide an ever-more-accurate view into the role of genes and cell
interactions in brain development. Our focus will be on the mouse
cerebellum due to the simplicity and knowledge base of its development.
We propose to adapt and create tools for examining and visualizing the
role of gene expression in cellular and molecular development of the
cerebellum. The goal is that these tools (informatic, validation and
visualization) will be readily accessible to researchers on-line and
provide the framework for a series of integrated science information
archives for the understanding of cerebellar development at multiple
levels of analysis.
