A Framework for Integration and Analysis of Multilevel Omics Data

Principal Investigator:
Michael A. Langston, Department of Electrical Engineering and Computer Science, University of Tennessee
Based on the study of more than 100,000 bacterial genomes, roughly 500 known functional protein domains appear to be conserved across all bacterial life. The main aim of this project is to reduce this set of domains to a much smaller set of biological functions. In so doing, it is hoped that we can distill and highlight a core collection of functions across bacteria and, hopefully, by extension across all living organisms. Data sources used in this effort include Pfam, BioCyc and StringDB. An intermediate goal is to identify a set of regulatory, functional and pathway-centric gene networks common to these domains.
Research Partner:
David Ussery at the University of Arkansas for Medical Sciences (UAMS).