accurately acute adaptive administration against allotransplantation analysis animals anthrax applied approach associated between biology capturing cellular chemokines combined combining competition complex complexity computational control damage defense deficient derivation derived dynamics early elucidate endotoxemia endotoxin epizootic estimation fixed forward going hemorrhage immune immunity immunology induced infection inflammation inflammatory inhalation injury innate insights ischemia local lymphocyte macrophages mathematical mediators model modeling models modulate molecular nonlinear objective optimal organ parameter pathogen pathogens patterns point powerful predict predicting predictive preferentially reduced regional regulate repeated reperfusion research response responses rheostat robust scenarios silico simple simulations solid solving specific state strategies stressors synergy systemic systems therapeutic therapy transients translational trauma tuberculosis using within